This book constitutes the proceedings of the 35th International Conference on Architecture of Computing Systems, ARCS 2022, held virtually in July 2022. The 18 full papers in this volume were carefully reviewed and selected from 35 submissions.ARCS provides a platform covering newly emerging and cross-cutting topics, such as autonomous and ubiquitous systems, reconfigurable computing and acceleration, neural networks and artificial intelligence.The selected papers cover a variety of topics from the ARCS core domains, including energy efficiency, applied machine learning, hardware and software system security, reliable and fault-tolerant systems and organic computing.