This book constitutes the proceedings of the 15th IFIP Working Conference on the Practice of Enterprise Modeling, PoEM 2022, which took place in London, UK, during November 23-25, 2022. PoEM offers a forum for sharing experiences and knowledge between the academic community and practitioners from industry and the public sector.This year the theme of the conference is Enterprise Modeling and Model-based Development and Engineering. The 15 full papers presented in this volume were carefully reviewed and selected from a total of 45 submissions.They were organized in topical sections as follows: models in information system development; modeling enterprise architectures; modeling capabilities and ecosystems; DSML and meta-modeling; and participatory modeling.