In the past years, COVID-19 caused millions of deaths and severely damaged not only public health, but also the global economy.New variants continue to threaten human health. Thus, natural compounds for retarding infection are in high demand.This book summarizes the emerging research with flavonoids, whose application holds great promise of antivirus, anti-inflammation, antioxidative stress, and immunomodulatory.Topics include the role of flavonoids in preventing an inflammatory storm and how flavonoids interact with critical protein targets that are involved in the infection stages of COVID-19. Key Features• Highlights anti-SARS-CoV-2 drug discovery on natural products and medicinal plants• Includes all major subclasses of flavonoids that promisingly combat COVID-19 • Proposes molecular mechanisms of flavonoids against protein targets of SARS-CoV-2• Contributions from an international team of leading researchers• Provides recommendations with respect to the future research