This Element argues for a novel approach to the sciences within Thomism, namely, science-engaged Thomism, which, aligned with the recent science-engaged theology movement, asks theological and metaphysical questions that require the input of the natural sciences.Recent developments within Thomism show a new approach to the natural sciences, and, thus, the proposal is to encourage more of this discourse by portraying the differences between contemporary and past Thomism.Still, even if it takes a novel approach, science-engaged Thomism relies on a tradition of thought that possesses a vast arsenal of metaphysical tools.Thus, after presenting this approach and a concise introduction to some basic notions of Thomistic metaphysics, the Element reviews some theological and philosophical questions and their relation to the natural sciences: issues about creation, cosmology, and astrobiology, divine involvement in evolutionary biology, providence and indeterministic quantum processes, and some ideas for further development at the end.